Sim City for Mac is beautifully designed with an incredible amount of information and detail that really brings your city alive. However, the biggest gripe with Sim City for Mac is that you cannot play without being connected to EA's servers which had several teething problems on the PC version and it's shame that you can't just play offline. Whether you prefer to play alone or with others, it's enjoyable, but it's clearly designed more with multiplayer in mind. However, the cities are limited in size, and SimCity is more fun when you have multiple cities that cooperate and specialize.
When you start Sim City, you can either join a populated region which will have other online players in or start a fresh region yourself.